g:GOSt Gene Group Functional Profiling
 g:Cocoa Compact Compare of Annotations
 g:Convert Gene ID Converter
 g:Orth Orthology search
 g:SNPense Convert rsID
Welcome! Contact FAQ R / APIs Beta Archive
J. Reimand, T. Arak, P. Adler, L. Kolberg, S. Reisberg, H. Peterson, J. Vilo: g:Profiler -- a web server for functional interpretation of gene lists (2016 update) Nucleic Acids Research 2016; doi: 10.1093/nar/gkw199 (PDF, more)
[?] Organism

[?] Target organism

[?] Output type

[?] Query (genes, proteins, probes, term)

[?] Interpret query as chromosome ranges
[?] Numeric IDs treated as

Welcome to g:Orth!

g:Orth is a tool for mapping orthologous genes in related organisms. Ortholog genes are similar in sequence and are likely conserved through evolution since a common ancestor. Orhologous genes may also carry out similar function and are therefore relevant in functional analysis.

The input of g:Orth is a mixed list of IDs for genes or other biomolecules of one organism of interest. The user also needs to select a target organism; all genes in input are then mapped to the orthologous sequences of the target organism. Input IDs that have no corresponding entry in either the given organism or the target organism will be displayed as N/A. g:Orth ortholog mappings are based on Ensembl alignments. Orthologs are automatically mapped via Ensembl gene IDs using g:Convert.

In addition to tabular output, g:Orth shows a clickable PNG graphic that displays numbers of conserved genes in all species in g:Profiler.

  • Query 1: List of budding yeast transcription factors and corresponding genes in human.
  • Query 2: Same as above, but Excel Spreadsheet (XLS) produced as output (output format).
  • Query 3: Rapidly developing regions from the 1st chromosome of the human genome (according to Neanderthal genome analysis) and corresponding orthologs in G.gorilla (query with chromosomal regions).